Review Article
PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice
Table 1
Studies of reproductive phenotypes of female PPARα,
PPARβ/δ,
and PPARγ-null or transgenic mice.
| PPAR isotype | | Reproductive phenotypes | References |
| PPARα | KO | Maternal abortion and neonatal death;
altered ovarian estradiol production | Yessoufou et al. [20], Lefebvre et al. [4] | TG | Defect in mammary gland development;
defect in lactation during pregnancy | Yang et al. [50] | PPARβ/δ | KO | Placental defects;
frequent (>90%) midgestation lethality; placenta
lipid accumulation defects | Barak et al. [19],
Nadra et al. [57] |
PPARγ | KO | Embryonic
death at embryo day 10;
embryonic lipid droplets lacking; placental malformed labyrinth zone; toxic milk | Barak et al. [17],
Kubota et al. [18], Wan et al. [71] | TG | Exacerbates mammary gland tumor
development | Saez et al. [73] |
|
|
KO: global or tissue-specific knockout; TG: tissue-specific transgenic.
|