PPAR Action in Human Placental Development and Pregnancy and Its Complications

Table 5

PPAR in pregnancy-specific diseases.

PPAR	PPAR-action	Disease	Model	Reference
PPARγ	Reduced circulating PPARγ activators in serum from women with PE	PE	In vitro	Waite et al. [111]
	Placental 15dPGJ2level are decreased in diabetes	GDM	Murine	Capobianco et al. [95]
	Association of PPAR-γ2 Pro12Ala with weight gain	GDM	Human	Tok et al. [112]
	Placental 15dPGJ2levels are decreased	GDM	Human	Javerbaum et al. [113]
	Decreased	Hydatidiform mole	Human	Capparuccia et al. [114]
	Decreased	Choriocarcinoma	Human	Capparuccia et al. [114]
	Placental PPAR expression is not involved	IUGR	Human	Rodie et al. [115]
	Association of PPAR-γ2 Pro12Ala polymorphism	Preterm birth	Human	Meirhaeghe et al. [116]
PPARα	Lack of PPAR-α upregulates Th1 cytokines	Abortion/neonatal mortality	Murine	Yessoufou et al. [76]