Review Article
PPAR Action in Human Placental Development and Pregnancy and Its Complications
Table 3
PPAR knock out models and placental pathology (PRIP: peroxisome proliferator-activated
receptor-(PPAR) interacting protein; RAP 250: nuclear receptor-activating protein
250).
| PPAR knockout model | Placental pathology | Lethality | Reference |
| PPARα | No
significant effect on placentation | 20% | Yessoufou et al. [76] | PPARβ/δ | Poor
placentation | >90% | Barak et al. [77] | PPARγ | Poorly
developed labyrinth | 100% | Barak et al. [15]
Kubota et al. [82] | PPARγ coactivator PRIP | Reduced
spongiotrophoblast layer | 100% | Zhu et al. [79] | PPARγ coactivator RAP250 | Reduced
spongiotrophoblast layer | 100% | Antonson et al. [80] | RXRα
or β | Lack
of labyrinth zone | 100% | Sapin et al. [81] |
|
|