The Roles of PPARs in the Fetal Origins of Metabolic Health and Disease

Figure 1

PPAR isotype expression and programming during the reproductive cycle. The PPAR-β/δ and PPAR-γ isotypes regulate the growth of key organs and manage the development of adipose tissue during fetal development. During the later stages of fetal development epigenetic programming of PPAR-α (represented by the grey section of the arrow) programmes long-term postnatal regulation of energy metabolism.