Review Article

PPAR Signaling in Placental Development and Function

Figure 1

Trophoblast lineages in the developing mouse placenta. Shown from left to right are a blastocyst (E3.5), an E6.5 embryo, and an E9.5 embryo. Respective trophoblast lineages are traced for clarity. Al: allantois; Ch: chrion; CP: chorionic plate; De: decidua; Emb: embryo; EPC: ectoplacental cone; : primary giant cells; : secondary giant cells; ICM: inner cell mass; La: labyrinth; Sp: spongiotrophoblast; TE: trophectoderm. FGF4: fibroblast growth factor 4 secreted by the embryo to maintain the chorion. Blastocyst and E6.5 embryo picture courtesy of Drs. Mimi DeVries and Tom Gridley, respectively, The Jackson Laboratory.
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