Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS)

Froment, Pascal; Touraine, Philippe

doi:https://doi.org/10.1155/PPAR/2006/73986

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Volume 2006 | Article ID 073986 | https://doi.org/10.1155/PPAR/2006/73986

Thiazolidinediones and Fertility in Polycystic Ovary Syndrome (PCOS)

Pascal Froment¹and Philippe Touraine²

Received15 Jul 2006

Revised13 Oct 2006

Accepted17 Oct 2006

Published06 Nov 2006

Abstract

Polycystic ovary syndrome (PCOS) is the most frequent cause of female infertility. The treatment of PCOS patients with insulin sensitizers, such as metformin or thiazolidinediones, increases the ovulation rate and the number of successful pregnancies. The positive action of the insulin-sensitizing treatments could be explained by a decrease in the peripheral insulin resistance but also by a direct action at the ovarian level. We report in this review different hypotheses of thiazolidinediones actions to improve PCOS (steroid secretion by ovarian cells ; insulin sensitivity in muscle and adipocyte and fat redistribution).

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Copyright © 2006 Pascal Froment and Philippe Touraine. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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