In the last two decades, deep brain stimulation of the Subthalamic Nucleus (STN) and Globus Pallidus interna (GPi) has conquered an essential place in the management of Parkinson’s disease. Its success stems essentially from its reversible nature compared to the destructive lesions created during thalamotomy and pallidotomy and from its flexibility through programming that allows modification of the energy delivered to the specific brain targets in order to obtain maximal benefit with minimal side effects.

With constant progress in technology, exploration of new targets and programming paradigms, recent emphasis on the management of nonmotor symptoms of PD, and debate about patient selection and timing of surgery, a special issue on this topic is timely.

We hereby invite you to submit original research articles as well as review articles that will reflect the most up-to-date knowledge and questions about deep brain stimulation in Parkinson’s disease.

Potential topics include but are not limited to the following:

• Comparing GPI and STN DBS
• New potential targets of DBS in Parkinson’s disease (PPN, Zi, and so on)
• Patient selection
• Timing of surgery
• Impact of DBS on nonmotor symptoms
• Managing side effects from programming (e.g., gait, speech issues, and so on)
• Novelties on the surgical aspect (new imaging software for planning and new surgical approaches)
• Technological novelties (new type of electrodes and/or implantable pulse generators and adaptive DBS)