Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals

Table 2

Summary of test results. The improvement and worsening of lesion-induced parkinsonian symptoms by DBS are marked by (+) and (−), respectively. Borderline changes are marked by (b); parameters with no detectable DBS effects are marked (0); n.d. stands for “not determined.” The results marked with an asterisk could not be interpreted in terms of the therapeutic DBS effects.

Group name	Rotation test	Stepping test; initiation time	Stepping test contralateral bias		Corridor test	Open-field test
		Contralateral paw	Forehand	Backhand		Total distance	Distance
6-OHDA_bi_3 d	b+	+	0	0	0	—	Up
6-OHDA_bi_3 w	b+	b+	0	0	0	—	0
6-OHDA_uni_ 3 d	+	b−	0	0	0	—	0
6-OHDA_uni_ 3 w	+	0	0	0	+	0	Up
6-OHDA_uni_ 3 w + 3 d off	0	0	0	0	n.d.	+	Up
6-OHDA_uni_ 6 w	0	b+	—	0	0	b−	Up
6-OHDA_uni_ 3 w + 3 w off	0	+	0	0	b+	0	0