Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals

Figure 11

Short-term and long-term effects of DBS with uni- and bipolar electrodes on the locomotor activity of hemiparkinsonian rats as measured by the total migration distance in the open field. (a) and (b) refer to test groups and controls, respectively. Different column patterns indicate different times of behavioral testing; white: before 6-OHDA or sham lesion; black: 12–14 days after 6-OHDA or sham lesion; gray and hatched: after the durations of DBS or sham stimulation indicated in the group labels. For experimental details see Table 1. Significance levels are indicated with asterisks as follows: , , b (borderline): according to one-way ANOVA. Asterisks above black columns refer to white columns; all others refer to black columns.

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