Cognitive Impact of Deep Brain Stimulation on Parkinson’s Disease Patients

Table 4

Studies comparing cognitive outcomes between GPi and STN DBS in PD patients.

Author, year	N STN/GPi	Laterality	F/u (mo)	Status of stimulation/medication at cognitive assessment	Cognitive measures assessed	Differences between GPI and STN
Boel et al., 2016 [55]	63/65	BL	36	ON/ON	GC, A/C, E, M, L	None
Follett et al., 2010 [52]	147/152	BL	24	ON/OFF	GC, L, V, E, M	None
Odekerken et al., 2013 [26]	63/65	BL	12	ON/integrated ON and OFF	Composite test	None
Odekerken et al., 2015 [54]	56/58	BL	12	ON/ON	A/C, E, M, L, V	4/11 measures of A/C worse with STN
Odekerken et al., 2016 [34]	43/47	BL	36	ON/ON	A/C, E, M, composite score	None
Okun et al., 2009 [51]	22/23	UL	7	ON/OFF	L	None
Rothlind et al., 2007 [50]	19/23	UL	6	ON/ON	A/C, E, L, V, M	None
Rothlind et al., 2007 [50]	14/15	BL	21	ON/ON	A/C, E, L, V, M	None
Rothlind et al., 2015 [47]	84/80	BL	6	ON/ON	A/C, E, GC, L, M	None overall, E worse with STN, M worse with Gpi
Weaver et al., 2012 [53]	70/89	BL	36	ON/OFF	GC, L, V, E, M	M worse with STN

PD: Parkinson’s disease; GPi: globus pallidus interna; STN: subthalamic nucleus; N: number of patients; mo: months; UL: unilateral; BL: bilateral; A/C: attention/concentration; E: executive; GC: global cognition; L: language; M: memory; V: visual. Adapted from Mehanna [101] with permission from the author.