Blood Plasma of Patients with Parkinson’s Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity

Figure 5

Effects of NS and PD plasma on α-syn oligomerization and phosphorylation in neuronal culture medium. ((a)–(d)) Recombinant human α-syn (5 µM) was added to medium containing 30% NS or PD plasma for 14 d. Oligomeric α-syn and pS-α-syn levels were examined by western blotting ((a), (b)) and ELISA ((c), (d)) (/group; one-way ANOVA followed by Tukey’s post hoc test). , versus control group.

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