N-Acetylcysteine in Combination with IGF-1 Enhances Neuroprotection against Proteasome Dysfunction-Induced Neurotoxicity in SH-SY5Y Cells

Figure 6

The autophagy inhibitor 3-methyladenine (3-MA) attenuates MG132 induced PARP and caspase 3 cleavage. The cells were pretreated with 3-MA (1 mM) for 1 h and then treated with MG132 for 24 h. (a) Western blot analysis for PARP, cleaved PARP, and cleaved caspase 3. Densitometric analysis for cleaved PARP (b) and cleaved caspase (c) from three independent experiments. Level of significance is denoted as .

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