N-Acetylcysteine in Combination with IGF-1 Enhances Neuroprotection against Proteasome Dysfunction-Induced Neurotoxicity in SH-SY5Y Cells

Figure 5

Pretreatment with IGF-1 and NAC represses MG132 induced ER stress. The cells were pretreated with IGF-1 and NAC, alone or together, for 18 h, followed by addition of MG132 (5 µM) for 24 h. (a) Western blot analysis for CHOP (an ER stress marker). Data are representative of three separate experiments. (b) Densitometric analysis of CHOP from three independent experiments. Level of significance is denoted as .

(a)

(b)