Clinical Study
Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease
Table 1
Association analysis of MTIF3 rs7669 genotype and allele frequencies in Parkinson’s disease (PD).
| MTIF3 | Familial PD (n= 90) | Sporadic PD (n= 291) | Combined samples (n= 381) | Controls (n= 322) |
| Genotypes | | | | | CC (%) | 59 (65.6) | 168 (57.7) | 227 (59.6) | 211 (65.5) | CT (%) | 28 (31.1) | 108 (37.1) | 136 (35.7) | 96 (29.8) | TT (%) | 3 (3.3) | 15 (5.2) | 18 (4.7) | 15 (4.7) | | | | | | Alleles | | | | | C (%) | 146 (81.1) | 444 (76.3) | 590 (77.4) | 518 (80.4) | T (%) | 34 (18.9) | 138 (23.7) | 172 (22.6) | 126 (19.6) | | | | | | Odds ratio | 1.045 (0.686–1.59) | 0.783 (0.596–1.03) | 0.834 (0.644–1.08) | | Combined genotypes | | | | | CC/CT (%) | 87 (96.7) | 276 (94.8) | 363 (95.3) | 307 (95.3) | TT (%) | 3 (3.3) | 15 (5.2) | 18 (4.7) | 15 (4.7) | | | | | | Odds ratio | 1.42 (0.401–5.01) | 0.899 (0.432–1.87) | 0.985 (0.488–1.99) | | TT/CT (%) | 31 (34.4) | 123 (42.3) | 154 (40.4) | 111 (34.5) | CC (%) | 59 (65.6) | 168 (57.7) | 227 (59.6) | 211 (65.5) | | | P = .0473
| | | Odds ratio | 0.999 (0.612–1.63) | 1.39 (1.01–1.93) | 1.29 (0.948–1.75) | |
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aChi-square test (χ 2) (2DF) for contingency table, (1DF) for contingency table.
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