Detection of Prostate Cancer Antigen 3 and Prostate Cancer Susceptibility Candidate in Non-DRE Urine Improves Diagnosis of Prostate Cancer in Chinese Population

Figure 1

The exosomal RNA expression of PCA3/PRAC in non-DRE urine is increased in prostate cancer. (a) Urine RNA expression of PCA3 is normalized to PSA and is relatively high in the biopsy-positive (PCa) group, when compared with the biopsy-negative (BPH/PIN) group. (b) A higher expression of PCA3 is observed in the high-grade prostate cancer cohort. (c, d) Urine RNA expression of PRAC is normalized to PSA and is decreased in the biopsy-positive (PCa) group and in the low-grade prostate cancer group. (e, f) The exosomal PCA3/PRAC is significantly higher in the biopsy-positive (PCa) group and is increased by the Gleason score. High-grade PCa, Gleason score ≥7 (n = 8); low-grade PCa, Gleason score = 6 (n = 6); BPH, benign prostatic hyperplasia; PIN, prostatic intraepithelial neoplasia. The Mann–Whitney U test is used for statistical analysis. Data are presented as mean ± SEM.

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