Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer

Table 2

List of the 61-gene signature containing both germline and somatic mutations found to be significantly differentially expressed between aggressive tumors and controls. indicates the gene containing genetic variants directly associated with aggressive PCa.

	GWAS			DE
Genes	Chrom	SNP_ID	P value	Germline	Somatic	P value
PGBD1	6p22.1	rs1233708	0.004	1	2	0.02169
OXR1	8q23	rs16901979	0.002	1	1	1.52E-20
GZF1	20p11.21	rs6076072	0.01	1	1	2.42E-12
ITGAX	16p11.2	rs8045738	0.006	1	1	1.20E-11
ORC3	6q15	rs9450716	0.002	1	1	3.31E-06
BMPR1B	4q22	rs17021918	0.03	1	1	3.17E-06
KLK3	19q13.41	rs2739472	9.00E-186	15	1	4.43E-13
KLK2	19q13.33	rs1354774	6.00E-20	5	1	4.53E-19
NKX3-1	8p21.2	rs13272392	4.00E-34	4	1	3.30E-20
SLC22A3	6q25.3	rs4646284	3.20E+52	4	1	6.62E-11
RNASEL	1q25	rs486907	0.004	3	1	8.88E-26
ZNF827	4q31.22	rs56935123	4.00E-09	2	3	9.16E-06
FGFR2	10q26.12	rs10886902	2.00E-53	2	1	8.24E-29
HOXB13	8q24.21	rs188140481	6.00E-34	2	1	2.36E-27
PDLIM5	4q22	rs17021918	4.20E-15	2	1	1.36E-21
POU5F1B	8q24.21	rs16901979	1.00E-16	2	1	4.94E-17
SLC19A2	1q23.3	rs3765227	1.26E-04	2	1	6.46E-11
ITGA6	2q31.1	rs126212278	0.001	2	1	5.56E-10
TBX5	12q24.1	rs1270884	6.75E-11	2	1	1.53E-09
SLC41A1	1q32.1	rs6679073	4.00E-15	2	1	0.026695
LRP1B	2q21.2	rs10210358	2.00E-06	1	10	7.28E-33
PKHD1	6p21.2	rs10498792	3.00E-06	1	4	0.01337
ATF7IP	12p13.1	rs3213764	2.00E-09	1	3	1.13E-06
FREM1	9p22.3	rs1552895	0.002	1	3	7.30E-05
BCL11A	2p16.1	rs2556375	6.00E-19	1	2	2.02E-17
SIX1	14q23.1	rs7153648	2.00E-09	1	2	4.77E-16
DNAH5	5p15.2	rs4463179	2.00E-06	1	2	8.71E-16
PRDM15	21q22.3	rs6586243	7.79E-06	1	2	6.34E-13
GLI2	2q14	rs11122834	5.00E-06	1	2	1.28E-11
TRIM31	6p22.1	rs115457135	1.00E-07	1	2	4.61E-11
TCF7L2	10q25.3	rs7903146	0.009	1	2	1.43E-08
KIAA1211	4q12	rs629242	7.25E-07	1	2	5.48E-06
MDM4	1q32	rs4245739	2.01E-11	1	2	9.95E-05
TBX3	12q24.21	rs11067228	1.00E-14	1	2	0.000208
LMTK2	7q22.1	rs6465657	0.007	1	2	0.00243
STAT3	17q21	rs744166	0.03	1	2	0.002775
IL16	15q26.3	rs7175701	9.80E-08	1	2	0.026789
EPHA10	1p34.3	rs731174	5.00E-06	1	1	1.44E-35
FERMT2	14q22.1	rs8008270	1.78E-14	1	1	3.20E-30
FTO	16q12.2	rs9939609	0.04	1	1	6.96E-16
BMPR1A	10q22.3	rs11597689	0.03	1	1	1.09E-13
EIF2S3	Xp22.11	rs6627995	1.00E-13	1	1	1.21E-12
TTC7A	2p16.3	rs10194115	5.00E-07	1	1	1.81E-11
NAALADL2	3q26.31	rs78943174	4.00E-08	1	1	4.07E-10
PPFIBP2	11p15.4	rs12791447	4.00E-08	1	1	5.20E-10
KCNN3	1q21.3	rs1218582	1.95E-08	1	1	9.96E-10
AMIGO2	12q13.11	rs2711721	2.00E-06	1	1	2.17E-09
ZNF652	17q21.32	rs7210100	3.40E-13	1	1	5.55E-09
MYO6	6q14.1	rs9443189	4.00E-08	1	1	2.71E-08
EBF2	8p21.2	rs11135910	8.00E-11	1	1	8.98E-08
TBX1	22q11.21	rs2238776	2.00E-08	1	1	7.97E-08
PTGFRN	1p13.1	rs2806864	6.00E-07	1	1	2.52E-07
TNC	9q33.1	rs7847271	4.00E-06	1	1	3.93E-07
ATP9B	18q23	rs7241993	2.00E-09	1	1	4.37E-06
HAPLN1	5q14.3	rs4466137	3.00E-06	1	1	6.25E-05
NOTCH4	6p21.3	rs3096702	4.78E-09	1	1	5.81E-05
VGLL3	3p12.1	rs9757252	5.00E-06	1	1	7.72E-05
IKZF2	2q13.1	rs7569918	8.85E-04	1	1	9.51E-05
KLF4	9q31.2	rs817826	5.00E-14	1	1	0.002599
TNS3	7p12.3	rs56232506	9.00E-09	1	1	0.007265
DDHD1	14q22.1	rs8008270	2.00E-14	1	1	0.008911

Note. DE indicates differential expression.