Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer
Table 1
List of the 34-gene signature containing the most highly somatically mutated genes (≥ 5 Mutation events) that were significantly differentially expressed between aggressive tumors and controls.
Genes
Region
Mutation events
DE P value
SPOP
17q21.33
29
2.13E-25
ATM
11q22.3
13
0.004526
FOXA1
14q21.1
12
1.41E-31
KMT2C
7q36.1
12
0.04799
LRP1B
2q22.1
10
5.18E-31
FAT3
11q14.3
9
1.69E-39
OBSCN
1q42.13
9
7.66E-05
FREM2
13q13.3
8
4.60E-12
CSMD3
8q23.3
8
0.000312
KIF16B
20p12.1
8
0.020567
PCDH18
4q28.3
7
2.00E-15
SYNE1
6q25.2
7
1.12E-07
AHNAK
11q12.3
7
6.32E-06
PLCB4
20p12.3
7
0.000102
FAT2
5q33.1
6
2.13E-31
FAM83B
6p12.1
6
8.65E-31
DCHS2
4q31.3
6
4.08E-27
CDH23
10q22.1
6
1.01E-26
MACF1
1p34.3
6
9.90E-06
FLG
1q21.3
6
2.97E-05
PIK3CA
3q26.32
6
3.39E-05
VPS13D
1p36.22
6
4.42E-05
HFM1
1p22.2
6
0.003362
PTPRD
9p24.1
6
0.017381
EPHB1
3q22.2
5
9.49E-41
KIAA1614
1q25.3
5
6.36E-26
AHNAK2
14q32.33
5
8.04E-26
MXRA5
Xp22.33
5
2.48E-07
SACS
13q12.12
5
7.04E-07
ASH1L
1q22
5
6.85E-05
RYR2
1q43
5
8.91E-05
CTNNB1
3p22.1
5
0.000345
MT-ND5
21q22.3
5
0.014434
FZD4
11q14.2
5
0.042185
Note. DE indicates differential expression. indicates genes associated with aggressive PCa.
