Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer

Figure 5

Molecular networks showing interactions among genes containing both germline and somatic mutations. Gene names (symbols) are presented in the nodes. Gene names in purple color font contain both germline and somatic mutations. Gene names in blue color fonts indicate genes with more >5 somatic mutations, gene names in green font indicate genes containing germline mutations only, and gene names in red font indicate genes containing germline mutations directly associated with aggressive prostate cancer. Note that the networks were filtered to remove spurious connections. The colors red and black represent overlap in functional relations among genes in merged networks.