The Prognostic PDE4D7 Score in a Diagnostic Biopsy Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes

Figure 3

(a) Decision curve analysis in the diagnostic biopsy (DB) patient cohort of the net benefit of four different treatment decision strategies for men at risk of disease recurrence within 5 years after surgery. In total 45 of the 151 investigated patients failed the initial primary treatment of surgery by PSA recurrence (29.8%) within 5 years after intervention. Treatment strategies were tested for their net benefit across indicated threshold probabilities (0.05 step size) to trigger prostate surgery based on the probability of future disease recurrence. The CAPRA scores and the CAPRA & PDE4D7 scores were converted into 5-year BCR probabilities with logistic regression on the RP cohort (n=449 men with completed 5-year follow-up) before estimating net benefit. (b) Net reduction analyses demonstrating in how many patients a resection can be avoided based on the predicted risk of BCR derived from the CAPRA score and CAPRA & PDE4D7 score model, respectively.

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