5 y FU, recurrence (Phoenix criteria): 1 y 0%, 2 y 0%, and 3 y 62.7% Pre-GI grade I, 13.3%, grade II, 6.7%, post-GI grade I, 13.3, grade II, 0% Pre-GU grade I, 33.3%, grade II, 60.0%, grade III, 6.7% Post-GI: grade I, 6.7%, grade II, 60.0%, grade III, 33.3% Pre ED: grade I, 26.7%, grade II, 53.3%, grade III, 0% Post ED: grade I, 13%, grade II, 66.7%, grade III, 13.3%
LDR 124 Gy × 1 fx Single patient s/p EBRT 75 Gy for IR disease, Salvage at 4 years
100%, 100% 0.00cc 54.52%
Median FU 1 month, PSA at one year 0.52 and decreasing Postsalvage: no ED, nocturia 0-1x, 1-2 hr daily voiding AUA 21 from baseline of 5, SHIM score 22 (No ED) 3 months: GU and GI symptoms back to baseline
Median FU 36 months, recurrence (Phoenix criteria): 15% (3 of 6 no initial response) Presalvage ED: grade II, 50%, grade III, 25%, 3 yr ED: grade II, 35%, grade III, 20% Presalvage GI grade I, 45%, grade II, 10%, 3 yr GI grade I, 13.3%, grade II, 15% Presalvage GU grade I, 25%, grade II, 10%, 3 yr GU grade I, 5%, grade II, 15% Only one patient: grade III toxicity (GU) at 3 years FU
LDR Pd-103, prospective IR patients with Gleason ≤ 6. Total prostate treated with dose painting (GTV goal D100 200% and same OAR constraints as typical plan)
Biological recurrence: 0% at 31.5 months Acute (less than 6 months), late (greater than 6 months) Acute proctitis grade I, 23%, grade II, 0%, late proctitis grade I, 0%, grade II, 17% Acute urgency/frequency grade I, 54%, grade II, 46% Late urgency/frequency grade I, 58%, grade II, 17% Acute ED: grade I, 31%, grade II, 54%, grade III, 0% Late ED: grade I 33%, grade II, 42%, grade III, 17% No grade III toxicity
No
FU: follow-up, GU: genitourinary, GI: gastrointestinal, Salv.: salvageable, LR: low risk, IR: intermediate risk, HR: high risk, reg: registered, ED: erectile dysfunction, NR: not reported, TTI: tissue-type imaging, IPSS: International Prostate Symptom Score, IIEF-5: 5-item version of the International Index of Erectile Function. Would be salvageable given data if not salvage therapy. Would not be salvageable given data if not salvage therapy.