Research Article
Obesity and the Odds of Weight Gain following Androgen Deprivation Therapy for Prostate Cancer
Table 2
Univariate and multivariate odds ratios for the risk of ≥10 lbs weight gain 6 months after randomization for each clinical factor.
| Clinical factor | Number of men | Number of men who gained ≥10 lbs by EOT | Univariable analysis | Multivariable analysis | OR (95% CI) | value | AOR (95% CI) | value |
| RT | 85 | 2 | 0.18 (0.04, 0.86) | 0.03 | 0.18 (0.04, 0.89) | 0.04 | RT + AST | 86 | 10 | 1 (Ref) | — | 1 (Ref) | — | BMI increase per kg/m2 | 171 | 12 | 1.18 (1.05, 1.33) | 0.01 | 1.15 (1.01, 1.31) | 0.04 | PSA increase per ng/mL | 171 | 12 | 0.98 (0.90, 1.06) | 0.58 | 0.97 (0.87, 1.08) | 0.57 | Age | 171 | 12 | 0.93 (0.85, 1.02) | 0.14 | 0.95 (0.85, 1.06) | 0.38 | Gleason score 8 to 10 | 26 | 3 | 2.09 (0.39, 11.15) | 0.39 | 1.17 (0.17, 7.93) | 0.87 | 7 | 94 | 6 | 1.091 (0.26, 4.56) | 0.90 | 0.55 (0.10, 3.06) | 0.49 | 6 or less | 51 | 3 | 1 (Ref) | — | 1 (Ref) | — | T2 | 88 | 8 | 1.98 (0.57, 6.82) | 0.28 | 1.99 (0.49, 7.99) | 0.33 | T1 | 83 | 4 | 1 (Ref) | — | 1 (ref) | — | Mod to Sev cm | 41 | 5 | 2.44 (0.73, 8.15) | 0.15 | 2.11 (0.54, 8.26) | 0.28 | No or min cm | 130 | 7 | 1 (Ref) | — | 1 (Ref) | — |
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RT indicates radiotherapy; ADT: androgen deprivation therapy; BMI: body mass index; PSA: prostate-specific antigen; cm: comorbidity; OR: odds ratio; CI: confidence interval; AOR: adjusted odds ratio; EOT: end of treatment.
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