Prostate Cancer / 2012 / Article / Tab 3 / Research Article
Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men Table 3 South African and Senegalese case-control genotype associations with prostate cancer (adjusted for age).
Variables of interest South Africa Senegal White Mixed Black Senegalese Genotypes OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) CYP3A4 (rs2740574) AA 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref) AG 3.32 (1.52–7.24 )*3.38 (2.13–5.35 )**0.21 (0.03–1.32) 1.51 (0.52–4.38) GG — 4.57 (1.63–12.85) — 0.94 (0.54–1.65) AG/GG 3.63 (1.68–7.84 )*3.74 (2.37–5.89 )**0.18 (0.03–1.16) 1.13 (0.40–3.22) CYP3A5 (rs776746) GG 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref) AG 1.14 (0.55–2.37) 1.68 (1.02–2.76) 1.31 (0.36–29.51) 0.98 (0.18–5.39) AA 1.14 (0.46–2.79) 1.21 (0.89–1.64) 1.65 (0.38–7.15) 0.99 (0.50–1.99) AG/AA 1.17 (0.59–2.32) 1.61 (1.01–2.57) 2.21 (0.12–39.39) 0.98 (0.24–3.97) SRD5A2 V89L (rs523349) GG 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref) CG 0.71 (0.41–1.24) 0.74 (0.48–1.16) 0.26 (0.04–1.54) 0.36 (0.12–1.07) CC 0.86 (0.49–1.50) 0.78 (0.41–1.48) 0.17 (0.04 –0.66 )*0.98 (0.60–1.59) CG/CC 0.71 (0.41–1.22) 0.73 (0.47–1.13) 0.14 (0.03 –0.66 )*0.74 (0.30–1.86) SRD5A2 A49T (rs9282858) GG 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref) AG 1.02 (0.54–1.95) 2.31 (1.45 –3.68 )**0.43 (0.11–1.69) — AA — — — — AG/AA 1.02 (0.54–1.95) 2.31 (1.45 –3.68 )**0.43 (0.11–1.69) —
—: too few/no genotypes to estimate ORs.
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