Oxidative Medicine and Cellular Longevity

Nutrients and Diet: A Relationship between Oxidative Stress, Aging, Obesity, and Related Noncommunicable Diseases


Status
Published

1University of Chile, Santiago, Chile

2UND Life Sciences, Ohio, USA

3University of Granada, Granada, Spain


Nutrients and Diet: A Relationship between Oxidative Stress, Aging, Obesity, and Related Noncommunicable Diseases

Description

The significant increase in the prevalence of obesity currently observed in the world is directly associated with an increased risk of developing noncommunicable diseases such as diabetes, cardiovascular disease, nonalcoholic fatty liver disease, inflammatory diseases (autoimmune diseases), cancer, and even neurodegenerative diseases.

In this context, obesity and related chronic diseases are not only limited to developed countries or to the adult population. In the last 20 years the greatest increase of the incidence of these diseases has been observed in developing countries and in the young population. In this regard, nutrients, diet chemical composition, and food preparation play a relevant and direct role in regulation of various metabolic and molecular pathways. The main factors that favor this incidence increase are (i) an excessive consumption of fat (especially saturated fat) and refined carbohydrates (fructose and sucrose) and (ii) a deficit in the consumption of fruits and vegetables (sources of natural antioxidants), dietary fiber, and polyunsaturated fatty acids n-3. These conditions would directly favor the development of (i) nutritional oxidative stress, (ii) obesity, (iii) obesity related noncommunicable diseases such as diabetes and cardiovascular disease, and (iv) cellular aging.

Recent basic clinical and epidemiological research has demonstrated the importance of preventing diet-induced oxidative stress as a way to reduce the risk of developing obesity and their associated chronic diseases, as well as cellular aging. Solid evidence establishes a relevant role of certain nutrients and/or bioactive compounds present in the diet as protective agents against nutritional oxidative stress at the molecular level. These effects are able to regulate (i) energy metabolism, (ii) various molecular pathways, (iii) gene expression, and (iv) cellular and organic aging. Specifically, nutritional oxidative stress, as well as lipotoxicity and glycotoxicity that accompany it, directly favors the development of a proinflammatory tissue state, which, together with the activation of various redox-sensitive pathways, generate a change in the activity of certain transcription factors and in gene expression, for example, by affecting cell viability.

The proposed special issue will be devoted to reviewing in depth how nutrients (micro and macro) and diet are related to oxidative stress, obesity, and cellular aging. The emphasis will be on the molecular aspects that allow projecting future interventions in the prevention and/or treatment of these conditions and diseases.

Potential topics include but are not limited to the following:

  • Oxidative stress in obesity related to cellular aging
  • Oxidative stress, obesity, and cellular aging regulation by diet and nutrients
  • Different nutrients (micro and macro) and bioactive compound (antioxidants) that regulate oxidative stress response in obesity
  • Oxidative stress in obesity and related noncommunicable diseases
  • Interaction between diet and oxidative stress in obesity and related noncommunicable diseases

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 7460453
  • - Editorial

Nutrients and Diet: A Relationship between Oxidative Stress, Aging, Obesity, and Related Noncommunicable Diseases

Rodrigo Valenzuela | Undurti N. Das | ... | Carolina G. Llorente
  • Special Issue
  • - Volume 2018
  • - Article ID 5109503
  • - Research Article

Attenuation of High-Fat Diet-Induced Rat Liver Oxidative Stress and Steatosis by Combined Hydroxytyrosol- (HT-) Eicosapentaenoic Acid Supplementation Mainly Relies on HT

Francisca Echeverría | Rodrigo Valenzuela | ... | Luis A. Videla
  • Special Issue
  • - Volume 2018
  • - Article ID 3124364
  • - Research Article

The Ability of Different Ketohexoses to Alter Apo-A-I Structure and Function In Vitro and to Induce Hepatosteatosis, Oxidative Stress, and Impaired Plasma Lipid Profile in Hyperlipidemic Zebrafish

Dhananjay Yadav | Suk-Jeong Kim | ... | Kyung-Hyun Cho
  • Special Issue
  • - Volume 2018
  • - Article ID 1861984
  • - Research Article

Di-(2-Ethylhexyl) Phthalate Increases Obesity-Induced Damage to the Male Reproductive System in Mice

Jian Zhao | Shi Ren | ... | Lingling Zhai
  • Special Issue
  • - Volume 2018
  • - Article ID 3232080
  • - Review Article

Preventive and Therapeutic Role of Functional Ingredients of Barley Grass for Chronic Diseases in Human Beings

Yawen Zeng | Xiaoying Pu | ... | Tao Yang
  • Special Issue
  • - Volume 2018
  • - Article ID 7487816
  • - Research Article

Dietary Total Antioxidant Capacity and Dietary Polyphenol Intake and Prevalence of Metabolic Syndrome in Polish Adults: A Nationwide Study

Małgorzata Elżbieta Zujko | Anna Waśkiewicz | ... | Wojciech Drygas
  • Special Issue
  • - Volume 2018
  • - Article ID 1538632
  • - Research Article

Antiaging of Cucurbitane Glycosides from Fruits of Momordica charantia L.

Xueli Cao | Yujuan Sun | ... | Jianhua Qi
  • Special Issue
  • - Volume 2018
  • - Article ID 5296168
  • - Research Article

Characterization of Portuguese Centenarian Eating Habits, Nutritional Biomarkers, and Cardiovascular Risk: A Case Control Study

A. Pereira da Silva | A. Valente | ... | M. Bicho
  • Special Issue
  • - Volume 2018
  • - Article ID 6709742
  • - Research Article

Role of Exercise-Induced Cardiac Remodeling in Ovariectomized Female Rats

Renáta Szabó | Zoltán Karácsonyi | ... | Anikó Pósa
  • Special Issue
  • - Volume 2018
  • - Article ID 4757893
  • - Review Article

Honey and Diabetes: The Importance of Natural Simple Sugars in Diet for Preventing and Treating Different Type of Diabetes

Otilia Bobiş | Daniel S. Dezmirean | Adela Ramona Moise
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate44%
Submission to final decision78 days
Acceptance to publication48 days
CiteScore4.520
Impact Factor4.868
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