Oxidative Medicine and Cellular Longevity

Alleviation of Drugs and Chemicals Toxicity: Biomedical Value of Antioxidants


Publishing date
01 Aug 2018
Status
Published
Submission deadline
30 Mar 2018

1Suez Canal University, Ismailia, Egypt

2Cairo University, Giza, Egypt

3Bourgogne Franche-Comté University, Besançon, France

4University of Oradea, Oradea, Romania

5University of Life Sciences, Lublin, Poland

6All India Institute of Medical Sciences, Bhopal, India


Alleviation of Drugs and Chemicals Toxicity: Biomedical Value of Antioxidants

Description

All chemicals, including drugs, natural products, antioxidants, or even oxygen and water, can be toxic if given in high quantity and frequency. A principle was assumed by the father of toxicology, Paracelsus, who mentioned that “the dose makes the poison” and this is considered as a core assumption of traditional toxicology. Recently, many research findings challenged this traditional dogma and concluded that even small amount of some chemicals, that is, endocrine disruptors, has many adverse effects on humans’ and animals’ health at all life stages. Toxicity is not affected only by doses, but it is a complicated multifactorial process affected by many issues including genetic predisposition and developmental exposures.

Generally, oxidative damage is considered as one of the main major mechanisms of drugs and chemical toxicity leading to deterioration of cellular macromolecules including lipid, protein, and DNA. Oxidative stress plays a crucial role in the pathogenesis of many inflammatory conditions and diseases (Parkinsonism, Alzheimer’s, hypertension, atherosclerosis, diabetes, cancer, and rheumatoid arthritis) either in human or animals or as a laboratory model. On the other hand, antioxidants have a wide range of biomedical activities and could be used alone or in combination with other therapies for prevention and/or treatment of many toxicities and diseases.

Understanding the disease pathogenesis and toxicity mechanism as well as molecular target of antioxidants remains the primary focus of many researchers for better preventive and therapeutic intervention. This special issue is dedicated to integrating the previous and the current use of antioxidants against drugs and chemicals toxicity.

We cordially invite investigators to contribute their original and review articles in our special issue.

Potential topics include but are not limited to the following:

  • Isolation, characterization, and pharmacological evaluation of antioxidants
  • Identification of novel antioxidant active constituents and their biological evaluation
  • Implication of antioxidants in disease prevention and treatment
  • Antioxidants roles in chemically induced inflammatory and disease models (cancer, diabetes, rheumatoid arthritis, atherosclerosis, and neurodegenerative disorders)
  • The therapeutic application of antioxidant against drugs and chemicals toxicity
  • Elucidation of mechanism of phytochemicals as a natural antidote
  • The molecular mechanism of herb-chemical and food-drug interaction

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 6276438
  • - Editorial

Alleviation of Drugs and Chemicals Toxicity: Biomedical Value of Antioxidants

Mohamed M. Abdel-Daim | Khaled Abo-EL-Sooud | ... | Rohit Saluja
  • Special Issue
  • - Volume 2018
  • - Article ID 1805354
  • - Research Article

Nitroso-Oxidative Stress, Acute Phase Response, and Cytogenetic Damage in Wistar Rats Treated with Adrenaline

Milena Radaković | Sunčica Borozan | ... | Zoran Stanimirović
  • Special Issue
  • - Volume 2018
  • - Article ID 9125601
  • - Research Article

Neuroprotective Effects of dl-3-n-Butylphthalide against Doxorubicin-Induced Neuroinflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Behavioral Changes

Dehua Liao | Daxiong Xiang | ... | Pei Jiang
  • Special Issue
  • - Volume 2018
  • - Article ID 4010395
  • - Review Article

The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease

Ya-Dan Wen | Hong Wang | Yi-Zhun Zhu
  • Special Issue
  • - Volume 2018
  • - Article ID 8989676
  • - Research Article

Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2-(4-Hydroxyphenyl) Amino-1,4-naphthoquinone in Rats

Javier Palacios | José Miguel Fonseca | ... | Fredi Cifuentes
  • Special Issue
  • - Volume 2018
  • - Article ID 5167524
  • - Research Article

Lycopene: Hepatoprotective and Antioxidant Effects toward Bisphenol A-Induced Toxicity in Female Wistar Rats

Haidy G. Abdel-Rahman | Heba M. A. Abdelrazek | ... | Aaser M. Abdelazim
  • Special Issue
  • - Volume 2018
  • - Article ID 1261356
  • - Research Article

Protective Effects of Fullerene C60 Nanoparticles and Virgin Olive Oil against Genotoxicity Induced by Cyclophosphamide in Rats

Fayza M. Aly | Amnah Othman | Mohie A. M. Haridy
  • Special Issue
  • - Volume 2018
  • - Article ID 6703296
  • - Research Article

Protective Effects of Miswak (Salvadora persica) against Experimentally Induced Gastric Ulcers in Rats

Mohamed A. Lebda | Ali H. El-Far | ... | Shaker A. Mousa
  • Special Issue
  • - Volume 2018
  • - Article ID 9506543
  • - Research Article

Hepatoprotective Activity of Vitamin E and Metallothionein in Cadmium-Induced Liver Injury in Ctenopharyngodon idellus

Yajiao Duan | Jing Duan | ... | Shiyong Yang
  • Special Issue
  • - Volume 2018
  • - Article ID 6926712
  • - Research Article

Oxidative Stress in the Muscles of the Fish Nile Tilapia Caused by Zinc Oxide Nanoparticles and Its Modulation by Vitamins C and E

Aaser M. Abdelazim | Islam M. Saadeldin | ... | Ali Alkaladi
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate44%
Submission to final decision79 days
Acceptance to publication48 days
CiteScore4.520
Impact Factor4.868
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