Oxidative Medicine and Cellular Longevity

Molecular Mechanisms Underlying Age-Related Ocular Diseases


Status
Published

1Università degli Studi di Pavia, Pavia, Italy

2University of Eastern Finland, Kuopio, Finland

3Queen’s University Belfast, Belfast, UK

4Medical University of Silesia, Katowice, Poland

5University of Minnesota, Minneapolis, USA


Molecular Mechanisms Underlying Age-Related Ocular Diseases

Description

In industrialised countries, the elderly population is predicted to increase from 25% to 40% by 2030. As a consequence, the functional decline associated with the ageing people creates a challenge to be met by the national healthcare systems. Among the age-related ocular pathologies, the WHO has identified some irreversible diseases, like age-related macular degeneration, diabetic retinopathy, and glaucoma as priority eye diseases, in terms of prevention of visual impairment and blindness. The lack of effective therapies for the prevention or cure of the diseases is mainly due to the insufficient understanding of these diseases at the molecular and cellular levels. In addition, novel cellular and animal models are needed to better understand the pathogenesis of age-related ocular diseases and to identify new biomarkers to predict the severity of these pathologies or the responsiveness to therapies.

Besides the aforementioned ocular diseases, ageing is a risk factor also for cataracts, retinal vein occlusion, ischemic optic neuropathy, corneal degeneration, and dry eye. Among the known factors inducing ageing and neurodegeneration, oxidative stress, inflammation, and impairment in protein clearance play a key role.

The purpose of this special issue is to publish high-quality research papers as well as review articles that shed light on the molecular and cellular responses to oxidative stress underlying the onset or progression of age-related ocular pathologies, thus helping to translate pioneering “bench to bedside” research into effective clinical strategies. Original high-quality contributions that are not yet published and are not currently under review by other journals or peer-reviewed conferences are sought. Ageing affects genetics, epigenetics, and biochemical and cellular pathways that regulate lifespan.

Potential topics include but are not limited to the following:

  • Molecular and cellular mechanisms, proteins, and signalling cascades linked to inflammation, neurodegeneration, oxidative stress response, and cellular repair
  • Changes in the gene expression or function of enzymes/structural proteins with a physiological role in the retina, optic nerve, or other ocular tissues
  • Changes in mechanisms controlling gene expression at transcriptional or posttranscriptional level (including microRNAs)
  • Alterations of protein folding or protein degradation pathways responsible for intracellular/extracellular deposits
  • Alterations in the content or signalling cascade of growth factors (VEGF, BDNF, PlGF, etc.), with special interest in those endowed with a neuroprotective role
  • Dysfunctions of mitochondria or other cellular organelles leading to derangement of essential biochemical processes in neurons
  • Alterations of proteins/signalling controlling apoptosis, differentiation, and proliferation
  • Molecules acting on the above targets that may be of pharmacological interest for ocular diseases, including those endowed with neuroprotective effects and/or targeting longevity pathways

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 8476164
  • - Editorial

Molecular Mechanisms Underlying Age-Related Ocular Diseases

Marialaura Amadio | Kai Kaarniranta | ... | Deborah A. Ferrington
  • Special Issue
  • - Volume 2018
  • - Article ID 2487473
  • - Research Article

FluoroGold-Labeled Organotypic Retinal Explant Culture for Neurotoxicity Screening Studies

Adrian Smedowski | Marita Pietrucha-Dutczak | ... | Joanna Lewin-Kowalik
  • Special Issue
  • - Volume 2018
  • - Article ID 5260976
  • - Research Article

Cyclodextrin Enhances Corneal Tolerability and Reduces Ocular Toxicity Caused by Diclofenac

Hamdy Abdelkader | Zeinab Fathalla | ... | Barbara Pierscionek
  • Special Issue
  • - Volume 2018
  • - Article ID 4956080
  • - Research Article

Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways

Nicoletta Marchesi | Natthakan Thongon | ... | Marialaura Amadio
  • Special Issue
  • - Volume 2018
  • - Article ID 8374647
  • - Review Article

Age-Related Macular Degeneration: New Paradigms for Treatment and Management of AMD

Luis Fernando Hernández-Zimbrón | Ruben Zamora-Alvarado | ... | Roberto Gonzalez-Salinas
  • Special Issue
  • - Volume 2017
  • - Article ID 6926485
  • - Research Article

Zinc Protects Oxidative Stress-Induced RPE Death by Reducing Mitochondrial Damage and Preventing Lysosome Rupture

Dinusha Rajapakse | Tim Curtis | ... | Heping Xu
  • Special Issue
  • - Volume 2017
  • - Article ID 5293258
  • - Review Article

Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?

Janusz Blasiak | Malgorzata Piechota | ... | Kai Kaarniranta
  • Special Issue
  • - Volume 2017
  • - Article ID 2825703
  • - Research Article

Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells

Sergio Davinelli | Flavia Chiosi | ... | Giovanni Scapagnini
  • Special Issue
  • - Volume 2017
  • - Article ID 9281519
  • - Research Article

Mitochondria-Targeted Antioxidant SkQ1 Prevents Anesthesia-Induced Dry Eye Syndrome

Evgeni Yu. Zernii | Olga S. Gancharova | ... | Ivan I. Senin
  • Special Issue
  • - Volume 2017
  • - Article ID 1420892
  • - Research Article

Effects of Novel Nitric Oxide-Releasing Molecules against Oxidative Stress on Retinal Pigmented Epithelial Cells

Valeria Pittalà | Annamaria Fidilio | ... | Claudio Bucolo
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate44%
Submission to final decision79 days
Acceptance to publication48 days
CiteScore4.520
Impact Factor4.868
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