Oxidative Medicine and Cellular Longevity

Oxidative Stress-Mediated Reperfusion Injury: Mechanism and Therapies


Publishing date
27 Dec 2013
Status
Published
Submission deadline
09 Aug 2013

Lead Editor

1Department of Anesthesiology, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong Kong

2Department of Pharmacology and Toxicology, Wright State University Boonshoft School of Medicine, 210 Health Sciences, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA

3Department of Cardiology, Affiliated Beijing AnZhen Hospital of Capital University of Medical Sciences, No. 3 Anzhen Li, Beijing 100029, China

4Department of Cell Biology & Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada


Oxidative Stress-Mediated Reperfusion Injury: Mechanism and Therapies

Description

Oxidative stress plays an important role in the pathogenesis of ischemia reperfusion injury. The mechanisms underlying ischaemia/reperfusion injury have been extensively studied using healthy tissues, yet less attention has been devoted to defining how the different risk factors such as diabetes and aging (situations that are associated with increased oxidative stress) may influence the degree of organ or cellular injury under pathological conditions like ischemia/reperfusion. While rapid production of large amount of reactive oxygen species (ROS), called oxidative burst, causes oxidative damage which contributes significantly to ischemia reperfusion injury, moderate elevation of ROS production induced by therapeutic interventions like ischemic or pharmacologic preconditioning may trigger cellular protective signaling pathways, leading to the attenuation of ischemia reperfusion injury.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular mechanism underlying ischemia/reperfusion injury under normal and diseased conditions to develop strategies to treat these pathological conditions. Potential topics include, but are not limited to:

  • Role of reactive oxygen species (ROS) in organ (heart, lung, brain, liver, kidney, and/or intestine) ischemia reperfusion injury under normal and diseased (e.g., diabetes and hypertension) conditions
  • Cellular protective signaling pathways that ROS may trigger that contribute to cellular repairing during ischemia reperfusion injury and the potential interplay between these pathways
  • Cardioprotection in aged and/or functionally impaired hearts
  • Role of reperfusion-induced oxidative stress and inflammation in mediating remote organ injury
  • Recent advances in preventing ischemia-reperfusion injury

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/oximed/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/oximed/oxin/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 373081
  • - Editorial

Oxidative Stress-Mediated Reperfusion Injury: Mechanism and Therapies

Zhengyuan Xia | Yanfang Chen | ... | Mengzhou Xue
  • Special Issue
  • - Volume 2014
  • - Article ID 906965
  • - Review Article

Global Consequences of Liver Ischemia/Reperfusion Injury

Constantinos Nastos | Konstantinos Kalimeris | ... | Nikolaos Arkadopoulos
  • Special Issue
  • - Volume 2014
  • - Article ID 376515
  • - Clinical Study

Aging Aggravates Nitrate-Mediated ROS/RNS Changes

Qian Fan | Lifen Chen | ... | Jing Hua Liu
  • Special Issue
  • - Volume 2014
  • - Article ID 294150
  • - Research Article

BMP-2 Overexpression Augments Vascular Smooth Muscle Cell Motility by Upregulating Myosin Va via Erk Signaling

Ming Zhang | Min Yang | ... | Jing-Hua Liu
  • Special Issue
  • - Volume 2014
  • - Article ID 282854
  • - Review Article

NADPH Oxidase 1 and Its Derived Reactive Oxygen Species Mediated Tissue Injury and Repair

Xiu-Jun Fu | Ying-Bo Peng | ... | Xiong Zhang
  • Special Issue
  • - Volume 2014
  • - Article ID 345105
  • - Research Article

Antiaging Properties of a Grape-Derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a Signaling Network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN

Somak Das | Goran Mitrovsky | ... | Dipak K. Das
  • Special Issue
  • - Volume 2013
  • - Article ID 378484
  • - Research Article

Differential MicroRNA Profiling in a Cellular Hypoxia Reoxygenation Model upon Posthypoxic Propofol Treatment Reveals Alterations in Autophagy Signaling Network

Zhuo Chen | Zhe Hu | ... | Liangqing Zhang
  • Special Issue
  • - Volume 2013
  • - Article ID 782497
  • - Research Article

Astragalus Polysaccharide Suppresses Skeletal Muscle Myostatin Expression in Diabetes: Involvement of ROS-ERK and NF-κB Pathways

Min Liu | Jian Qin | ... | Lei Wei
  • Special Issue
  • - Volume 2013
  • - Article ID 507832
  • - Research Article

The Protection of Salidroside of the Heart against Acute Exhaustive Injury and Molecular Mechanism in Rat

Yunru Wang | Peng Xu | ... | Xuebin Cao
  • Special Issue
  • - Volume 2013
  • - Article ID 678484
  • - Research Article

Nitroglycerine-Induced Nitrate Tolerance Compromises Propofol Protection of the Endothelial Cells against TNF-α: The Role of PKC-β2 and NADPH Oxidase

Shaoqing Lei | Wating Su | ... | Zhengyuan Xia
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate44%
Submission to final decision79 days
Acceptance to publication48 days
CiteScore4.520
Impact Factor4.868
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