Acute Exposure to Permethrin Modulates Behavioral Functions, Redox, and Bioenergetics Parameters and Induces DNA Damage and Cell Death in Larval Zebrafish

Figure 11

Effects of permethrin exposure (50 μg/L) in mitochondrial function of zebrafish larvae. (a) The analyzed mitochondrial function by HRR is presented with the abbreviation(s) of the complex(es) involved followed by the state of respiration measured: basal metabolic rate (routine), +glutamate, pyruvate and malate (CI LEAK), +ADP (CI OXPHOS), +succinate (CI+CII CII_OXPHOS), +FCCP (CI+CII ETS), +rotenone (CII ETS), +antimycin A (ROX, residual oxygen consumption). Average for the . (b) Respiratory control ratio (RCR) for complex I (). (c) Residual oxygen consumption relative to the maximum oxygen consumption capacity (ROX/ETS). (d) Analysis of bioenergetics capacity (CI_LEAK-CIoxphos). (e) Analysis of oxidative phosphorylation coupling efficiency (CI_LEAK/CI_OXIPHOS). Values are expressed as and analyzed by one-way ANOVA followed by Tukey post hoc or expressed as and analyzed by Kruskal-Wallis followed by Dunn’s post hoc. Groups not sharing letters indicate statistical differences () between the exposure groups at each state of respiration.

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