Overexpression of BRCA1 in Neural Stem Cells Enhances Cell Survival and Functional Recovery after Transplantation into Experimental Ischemic Stroke

<div>Reduced grafted cell apoptosis and oxidative stress by preincorporation of BRCA1 in NSCs. (a) 2 d after transplantation, immunostaining with GFP, TUNEL, and DAPI was performed. BRCA1 preincorporation significantly reduced the number of TUNEL-positive grafted cells. (b) Oxidative stress in grafted cells was elevated by immunostaining with GFP, DHE, and DAPI. BRCA1 overexpression markedly reduced DHE signals in implanted NSCs. 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Scale bar: 50 <i>μ</i>m.</div>

Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Overexpression of BRCA1 in Neural Stem Cells Enhances Cell Survival and Functional Recovery after Transplantation into Experimental Ischemic Stroke 

Figure 6 | Overexpression of BRCA1 in Neural Stem Cells Enhances Cell Survival and Functional Recovery after Transplantation into Experimental Ischemic Stroke 