Research Article

A Nonsense Mitochondrial DNA Mutation Associates with Dysfunction of HIF1α in a Von Hippel-Lindau Renal Oncocytoma

Figure 2

IHC analysis of HIF1α and its targets. (a, b) IHC for HIF1α in the renal oncocytoma (a) with a QS of 12 (, ) and in a normal kidney used as control (b) with a QS of 1 (, ). (c, d) IHC for CAIX in the renal oncocytoma (c) with a QS of 0 (, ) and in a clear cell renal cell carcinoma used as positive control (d) with a QS of 10 (, ). (e, f) IHC of GLUT1 in the renal oncocytoma (e) with a QS of 0 (, ) and in a hypoxic area of a neuroendocrine carcinoma of the ovary used as positive control (f) with a QS of 12 (, ). Magnification for all IHC images: 200x.