Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro

Figure 2

PCr decreased pathological changes in diabetic hearts. (a) Effects of PCr on heart size were reduced significantly in treated groups than the diabetic group. (b) Hematoxylin and eosin (H&E) staining of the heart tissue showed that PCr improved the striation of myocardial fibers arranged regularly in treated groups. (c) Effects of PCr on blood glucose levels were reduced remarkably in the treated groups than the STZ group. (d) Effects of PCr on myocardial and antioxidative enzyme activities: MDA level was decreased significantly in the PCr group than in the diabetic group; (e, f) SOD and GSH were increased in treated groups compared with diabetic groups indicating the antioxidant capacity agent was endangered in the diabetic myocardium. (g, h, i) Western blot investigation of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Data are introduced as the (). vs. control; and vs. the STZ group.

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