Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway

<div>Glycine attenuated CoCl<sub>2</sub>-induced mitochondrial ROS generation, restored the MPP, improved Mfn-2 protein levels, and alleviated autophagy in PC12 cells. (a) Mitochondrial ROS generation of each group was detected by MitoSOX and DAPI staining. (b) Mitochondrial membrane potential of each group was determined by TMRE and Hoechst staining. (c) Protein expression level of Mfn-2 from outer membrane of mitochondria was measured by immunofluorescence. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway 