Research Article

Sepiapterin Improves Vascular Reactivity and Insulin-Stimulated Glucose in Wistar Rats

Table 1

Metabolic parameters. Animal glucose (control , sepiapterin (SEP) ) and insulin (control , SEP ) concentrations were measured in animals with food ad libitum and following a 6-hour fast. Data are with significant effect of time, repeated-measures two-way ANOVA. Undetectable < assay limit of 0.02 ng/mL.

GroupWeight (g)Triglycerides (mg/dL)Glucose ad libitum (mg/dL)Glucose fasting (mg/dL)Insulin ad libitum (ng/mL)Insulin fasting (ng/mL)

Baseline
Control340 ± 1477 ± 875 ± 40.130 ± 0.02
SEP359 ± 1274 ± 271 ± 20.332 ± 0.070.110 ± 0.05

Endpoint
Control544 ± 2284.300 ± 25.1263 ± 279 ± 53.260 ± 0.730.468 ± 0.09
SEP557 ± 2388.350 ± 29.9558 ± 366 ± 23.835 ± 0.580.471 ± 0.1