Occupational Exposure to Pesticides in Tobacco Fields: The Integrated Evaluation of Nutritional Intake and Susceptibility on Genomic and Epigenetic Instability

Table 2

CBMN parameters, telomere length (bp), and global DNA methylation (%) results for nonexposed and exposed groups. Data presented as error (SE).

Parameters	Nonexposed ()	Exposed ()	value^c
CBMN
Micronucleus^a	2.9 ± 0.4	6.0 ± 0.5	<0.001
Nucleoplasmic bridge^a	2.6 ± 0.4	6.0 ± 0.5	<0.001
Nuclear buds^a	2.0 ± 0.4	4.0 ± 0.4	<0.001
Binucleated cells^b	61.3 ± 8.2	120.6 ± 8.4	<0.001
Apoptosis^b	3.4 ± 0.4	3.9 ± 0.6	0.479
Necrosis^b	3.6 ± 0.6	3.7 ± 0.8	0.978
Telomere length (bp)	4551 ± 145.5	4098 ± 105.3	0.015
DNA global methylation (%)	3.804 ± 0.206	3.023 ± 0.131	0.006

^aFrequency per 1000 BN cells; ^bfrequency per 500 cells; ^c value between nonexposed and exposed groups; unpaired -tests.