Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation

Figure 3

Stevia prevents oxidative damage in chronic liver damage. Liver lipid peroxidation (LPO) (a), reduced glutathione (GSH) (b), and glutathione peroxidase (GPx) (c) are shown. Each bar represents the mean value of experiments performed in duplicate ± SE. versus the control group; versus the CCl₄ group (). Protein levels of 4-hydroxynonenal (4-HNE) (d) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) (e) in liver sections were determined by Western blot analysis of control, CCl₄, CCl₄ + stevia, and stevia-treated rats. Each bar represents the mean value of experiments performed in duplicate ± SE (). β-actin was used as a control. The values are expressed as the fold increase of OD normalized to the control group values (control = 1). versus the control group; versus the CCl₄ group.

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