Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway

<div>EX527 abolished HKL-induced suppression on myocardial apoptosis in MI/R-injured diabetic myocardium. (a) Representative images of TUNEL staining (300x, bar = 100 <i>μ</i>m). The apoptotic cells were detected by TUNEL (green), and the nuclei were detected by DAPI (blue). (b) Myocardial apoptotic index. (c) Representative blots. (d) Bcl-2/Bax ratio. (e) Cleaved caspase 3 expression. (f) Cytosolic cytochrome <i>c</i> expression. (g) Representative blots. (h) SIRT1 expression. (i) Relative SIRT1 activity. (j) Nrf2 nuclear translocation. 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the T1D + MI/R + HKL group.</div>

Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway 

Figure 4 | Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway 