Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway

<div>EX527 abolished HKL-induced cardioprotective effects on MI/R injury in type 1 diabetic rats. (a) Representative M-mode images by echocardiography. Echocardiographic assessment was performed after 72 h of reperfusion. (b) Left ventricular ejection fraction (LVEF). (c) Left ventricular fractional shortening (LVFS). (d) Serum CK activity. (e) Serum LDH activity. (f) Representative digital images of heart sections by Evans blue and triphenyltetrazolium chloride (TTC) double staining. (g) Myocardial infarct size. 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the T1D + MI/R + HKL group.</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway 

Figure 2 | Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway 