Research Article

Glycine Increases Insulin Sensitivity and Glutathione Biosynthesis and Protects against Oxidative Stress in a Model of Sucrose-Induced Insulin Resistance

Table 1

General characteristics of the animals.

VariablesCCGSFSFG

Food intake (g/day/rat)22.7 ± 0.819.3 ± 1.512.5 ± 0.710.7 ± 1.3
Water intake (mL/day/rat)45.7 ± 2.746.5 ± 2.847.5 ± 2.944.5 ± 2.5
Energy intake (kcal/day/rat)315.6 ± 8.5305.5 ± 9.6360.1 ± 8.4356.7 ± 5.8
Body weight (g)448 ± 12467 ± 15475 ± 10466 ± 9
Intra-abdominal fat (g)6.4 ± 1.46.3 ± 1.923.4 ± 1.89.8 ± 1.9
Plasma TG (mg/dL)43.1 ± 7.532.8 ± 4.396.9 ± 7.175.0 ± 7.0
Liver TG (μmol/mg)77.5 ± 8.585 .5 ± 9.5217.7 ± 28.4155.7 ± 35.6
Plasma FFA (mM)0.7 ± 0.070.5 ± 0.11.2 ± 0.10.7 ± 0.1
Liver FFA (μmol/mg)78.5 ± 11.468.6 ± 2.5117.5 ± 27.662.5 ± 31.7
Chol (mg/dL)38.4 ± 12.847.9 ± 12.142.2 ± 13.255.1 ± 16.9
Glucose (mM)6.0 ± 1.05.5 ± 0.75.9 ± 1.26.4 ± 1.5
Insulin (pΜ)111.6 ± 23.4119.9 ± 28.4187.5 ± 36.5122.9 ± 19.6

Chol (cholesterol), glucose, and insulin were determined in plasma. TG (triglycerides) and FFA (free fatty acids) were determined in both liver homogenate and plasma. Values represent mean ± SD, different animals. (C versus SF) and (SFG versus SF).