Sirtuins Expression and Their Role in Retinal Diseases

Table 1

Certain major functions of sirtuins.

Name of the sirtuin (SIRT)	Functions	Subcellular localization
SIRT1	Cellular longevity, tumor promoter, tumor suppressor, inflammation, oxidative stress, glucose homeostasis, cell adhesion, cell metabolism	Nucleus
SIRT2	Mitotic check point, tumor promoter, tumor suppressor	Cytoplasm/nucleus
SIRT3	Tumor suppressor, tumor promoter, mitochondrial oxidation, stress responsive deacetylase	Mitochondria
SIRT4	Glutamine catabolism, TCA cycle, ADP-ribosylation	Mitochondria
SIRT5	Glycolysis, cancer metabolism, fatty acid oxidation, lysine succinylation, malonylation, glutarylation	Mitochondria
SIRT6	Telomere and genome stability, DNA repair, inflammation, glucose homeostasis	Nucleus
SIRT7	Ribosomal production	Nucleus (nucleoli)