TY - JOUR A2 - Queralt, Anna V. AU - Lauro, Maria Rosaria AU - Crascì, Lucia AU - Giannone, Virgilio AU - Ballistreri, Gabriele AU - Fabroni, Simona AU - Sansone, Francesca AU - Rapisarda, Paolo AU - Panico, Anna Maria AU - Puglisi, Giovanni PY - 2017 DA - 2017/11/02 TI - An Alginate/Cyclodextrin Spray Drying Matrix to Improve Shelf Life and Antioxidant Efficiency of a Blood Orange By-Product Extract Rich in Polyphenols: MMPs Inhibition and Antiglycation Activity in Dysmetabolic Diseases SP - 2867630 VL - 2017 AB - Alginate and β-cyclodextrin were used to produce easily dosable and spray-dried microsystems of a dried blood orange extract with antidysmetabolic properties, obtained from a by-product fluid extract. The spray-dried applied conditions were able to obtain a concentrate dried extract without the loss of AOA and with TPC and TMA values of 35–40% higher than that of the starting material. They were also effective in producing microparticles with 80–100% of encapsulation efficiency. The 2% sodium alginate was capable of improving the extract shelf life, while the beta-cyclodextrin (1 : 1 molar ratio with dried extract) prolonged the extract antioxidant efficiency by 6 hours. The good inhibition effect of the dried extract on the AGE formation and the MMP-2 and MMP-9 activity is presumably due to a synergic effect exerted by both anthocyanin and bioflavonoid extract compounds and was improved by the use of alginate and cyclodextrin. SN - 1942-0900 UR - https://doi.org/10.1155/2017/2867630 DO - 10.1155/2017/2867630 JF - Oxidative Medicine and Cellular Longevity PB - Hindawi KW - ER -