Research Article

Periodic Exposure of Keratinocytes to Cold Physical Plasma: An In Vitro Model for Redox-Related Diseases of the Skin

Table 1

Expression (fold change compared to untreated control) of tight and adherent junction proteins with at least one significant modulation throughout the time course of plasma treatment. Actin expression remained relatively unchanged.

Gene nameGene IDw2w6w8w10w12

OccludinOCLN1.32−1.15−2.11−2.02−1.86

Claudin 1CLDN1−1.11−2.32−1.38−1.011.04
Claudin 2CLDN22.172.111.401.48−1.26
Claudin 3CLDN31.971.68−4.12−2.41−1.27
Claudin 4CLDN41.663.19−1.021.001.08
Claudin 6CLDN61.592.52−1.161.37−1.99
Claudin 7CLDN71.07−1.38−2.03−1.56−1.08
Claudin 8CLDN81.05−10.46−1.86−1.311.06
Claudin 12CLDN121.422.211.671.781.28
Claudin 17CLDN171.86−1.70−1.93−2.66−2.61
Claudin 18CLDN184.86−1.11−1.27−1.74−1.81
Claudin 19CLDN191.86−2.46−2.41−1.041.38
Claudin 22CLDN2217.472.93−1.661.26−1.52
Claudin 23CLDN23−1.24−1.68−3.49−2.51−1.69

Zonula occludens protein 1TJP1 (ZO-1)1.683.061.14−1.091.10
Zonula occludens protein 2TJP2 (ZO-2)−1.05−2.27−2.26−1.53−1.07
Zonula occludens protein 3TJP3 (ZO-3)−1.62−2.60−1.45−1.08−1.39

Cadherin 2CDH24.7846.4911.741.566.26
Cadherin 3CDH31.372.101.701.261.25
Cadherin 4CDH41.663.19−1.021.001.08
Cadherin 5CDH51.362.06−1.061.781.15
Cadherin 7CDH71.851.971.322.292.27
Cadherin 9CDH92.53−3.54−3.35−2.47−2.51
Cadherin 10CDH102.141.321.311.631.20
Cadherin 13CDH13−1.192.953.403.34−1.09
Cadherin 16CDH163.55−1.47−1.42−1.821.11
Cadherin 18CDH182.04−1.142.481.18−1.02
Cadherin 19CDH192.32−1.35−1.34−1.35−1.31
Cadherin 20CDH205.801.762.351.67−1.14
Cadherin 23CDH233.071.022.481.471.90
Cadherin 24CDH241.532.831.611.251.06

α-actin 2ACTA21.10−1.212.701.411.06
β-actinACTB1.341.351.231.041.02
β-catenin 1CTNNB11.622.051.271.031.21