Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?

Figure 6

Prevention of the MeO-AMVN-induced oxidation of CL liposomes by incorporated natural antioxidants, SkQ1H₂ and HPMC. Conditions: pH-buffer A (see Section 2), 100 μM CL, 50 μM MeO-AMVN, and 40°C. (a, b) Kinetics of absorbance changes at 234 nm in the presence of 1 μM of tested incorporated antioxidants and in their absence (black line) over the whole time range (a) and only during the induction phase (b).