Oxidative Medicine and Cellular Longevity / 2016 / Article / Tab 1

Research Article

Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats

Table 1

Composition and toxicology of grape powder used in these studies.
(a) Chemical composition of freeze-dried grape powder (California table grape commission)

CompoundsTotalIndividual

Catechins22.06 mg/kg
 Catechin13.7 mg/kg
 Epicatechin8.36 mg/kg
Anthocyanins709.8 mg/kg
 Peonidin232.2 mg/kg
 Cyanidin156.2 mg/kg
 Malvidin321.4 mg/kg
Flavonols
 Quercetin148.7 mg/kg
 Kaempferol11.61 mg/kg
 Isorhamnetin23.9 mg/kg
Stilbenes
 Resveratrol1.51 mg/kg
Total polyphenols383 mg/100 g

(b) Toxicology of grape powder constituents

CompoundDose (per kg body wt/day)DurationToxicity

Direct catechins≤2500 mgChronic (90 days)Nontoxic [21]
Anthocyanins≤2000 mgChronic (90 days)Nontoxic [22]
Flavonoids≤5000 mgAcute (24 hrs)Nontoxic [23]
Resveratrol≤3000 mg4 weeksToxic [24]

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