Review Article

Endogenous Generation of Singlet Oxygen and Ozone in Human and Animal Tissues: Mechanisms, Biological Significance, and Influence of Dietary Components

Figure 9

Oxidation pathways of cholesterol 41, leading to the 7-hydroperoxide 44 during autoxidation, the 5-hydroperoxide 46 upon reaction with 1O2, and secosterol A (49) upon reaction with O3. Aldolization of 49 produces secosterol B (50). Hock cleavage of 46 predominantly produces secosterol 50 and minor amounts of 49. There is no evidence of formation of dioxetanyl derivatives.