Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases

Table 3

Modulation of mitochondrial targets by polyphenols.

Target	Polyphenol	Effect	References
AP-1	EGCG	Downregulation	[116]
Bad/Bax	Resveratrol	Downregulation	[112]
	Ferulic acid	Downregulation	[124]
Bcl-2	Lutein	Upregulation	[125]
	Baicalein	Upregulation	[126]
Cox-2	Lutein	Downregulation	[125]
	Hesperidin	Downregulation	[127]
	Hibiscus sabdariffa polyphenols	Downregulation	[128]
GCLM	Chrysin, apigenin, luteolin	Upregulation	[129]
GCLC	Chrysin, apigenin, luteolin	Upregulation	[129]
GPX	EGCG	Upregulation	[130]
	Red wine polyphenols	Upregulation	[131, 132]
	3,3′,5,5′-tetra-t-butyl-biphenyl-4,4′-diol	Upregulation	[133]
HO-1	Butein, apigenin	Upregulation	[129]
	Luteolin	Upregulation	[134]
IFN-γ	Quercetin	Downregulation	[135]
JNK	Quercetin	Downregulation	[135]
	EGCG	Downregulation	[116]
	Hibiscus sabdariffa polyphenols	Downregulation	[128]
JUN	Quercetin	Downregulation	[135]
SOD	Phloridzin	Upregulation	[136]