Supplemental Cellular Protection by a Carotenoid Extends Lifespan via Ins/IGF-1 Signaling in Caenorhabditis elegans
Table 1
Effect of AX on mean and maximum lifespans at 20°C in several age-related mutants.
Strain (condition)
Mean lifespan (days)
Max. lifespan (days)
N2 (control)
31.5 ± 6.4
25.5 ± 6.0
24.5 ± 5.1
43.8 ± 4.8
N2 (0.1 mM AX)
38.4 ± 5.3**
32.2 ± 9.1**
27.7 ± 5.7**
51.6 ± 6.0*
N2 (1 mM AX)
41.4 ± 6.5**
32.8 ± 8.7**
28.6 ± 6.4**
53.3 ± 6.1*
age-1 (control)
47.1 ± 15.1
40.1 ± 14.6
46.4 ± 14.7
77.6 ± 7.0
age-1 (0.1 mM AX)
50.2 ± 16.1
50.2 ± 16.8**
50.5 ± 13.1*
80.0 ± 7.8
age-1 (1 mM AX)
54.8 ± 14.7**
49.8 ± 17.6**
51.4 ± 12.9*
82.6 ± 8.2
daf-16 (control)
19.2 ± 2.8
19.3 ± 2.9
18.0 ± 4.2
24.6 ± 2.6
daf-16 (0.1 mM AX)
21.2 ± 4.0
20.1 ± 2.8
18.6 ± 3.5
27.6 ± 3.5
daf-16 (1 mM AX)
22.0 ± 4.7
19.6 ± 3.5
19.5 ± 2.9
28.6 ± 3.8
Results about mean lifespan are indicated as means ± SD from three independent experiments. Results about maximum lifespan are expressed as means ± SD of more than six determinations. values by -test with an asterisk (controls versus AX-treated conditions) significantly differ as follows; * and **.
