Ameliorative Effects of Herbal Combinations in Hyperlipidemia

Table 3

Effect of feeding different combinations on hepatic lipid profiles, HMG-CoA reductase activity and bile acid content (mg/gm).

Group	NC	HC	C-I	C-II	C-III
Total lipids	30 ± 2.9^d	126.8 ± 4.3^a (+322.76)	91.7 ± 3.1^bc (−27.72)	83.8 ± 3.2^c (−33.90)	101.3 ± 3.1^b (−20.10)
Total cholesterol	1.9 ± 0.1^d	36.1 ± 1.7^a (+1769.43)	24.9 ± 1.5^bc (−30.90)	23.5 ± 1.3^bc (−34.75)	29 ± 1.4^b (−19.53)
Triglycerides	3 ± 0.1^b	24.3 ± 1.4^a (+705.96)	20.2 ± 1.2^a (−17.00)	22.1 ± 1.7^a (−9.20)	22.3 ± 1.8^a (−8.50)
HMG CoA reductase*	2.8 ± 0.1^e	7.1 ± 0.1^a (−156.67)	6 ± 0.1^bc (+15.75)	5.8 ± 0.1^cd (+18.84)	6.2 ± 0.1^b (+12.93)
Bile acid	3.8 ± 0.1^d	6.9 ± 0.1^c (+83.55)	8.8 ± 0.1^a (+27.45)	9.2 ± 0.1^a (+33.09)	8 ± 0.1^b (+16.18)

Values: mean ± SEM (n = 6).
Figures in parentheses indicate percent increase (+) or decrease (−).
Within a row those with different superscripts are significantly different (P < 0.002).
*HMG-CoA reductase activity is inversely proportional to the ratio of HMG-CoA/mevalonate (absorbance of HMG-CoA/absorbance of mevalonate), that is, the increase in ratio corresponds to a decrease in enzyme activity.
Comparisons for the percentage were made between groups NC and HC; HC and C-I; HC and C-II; HC and C-III.