Obstetrics and Gynecology International

Epigenetic Regulation in Reproductive Medicine and Gynecologic Cancers


Publishing date
01 Jun 2010
Status
Published
Submission deadline
01 Feb 2010

1Department of Biomedical Sciences, Mercer University School of Medicine, 4700 Waters Avenue, Savannah, GA 31405, USA

2Divisions of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905, USA

3Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905, USA

4Women's Hospital, Zhejiang University School of Medicine, Xueshi Road Hangzhou 310006, China


Epigenetic Regulation in Reproductive Medicine and Gynecologic Cancers

Description

An increasing body of evidence indicates that DNA methylation-mediated epigenetic mechanisms play critical roles in the maintenance of normal female reproductive function and overall health. Specifically, numerous tumor suppressor genes, DNA repair genes, and steroid hormone receptors are silenced by methylation. Conversely, the imprinting mechanism is implicated in placental function and pathogenesis of the nonmalignant diseases preeclampsia and intrauterine growth retardation.

Despite the rapid progress in the last decade, important issues concerning the epigenetic pathway remain unaddressed. Although methylated genes are continuously identified, a little is known in regard to the specific targeting mechanism of such findings. Similarly, we often observe an epigenetic alteration and the associated phenotypic changes, yet the molecular pathways linking the two remain a puzzle. A more detailed characterization of the enzymes and factors involved in such pathways will expand our knowledge in these areas, thus opening windows of opportunity for clinical application of epigenetic approaches in early diagnosis, monitoring of treatment, and individualization of therapy.

We invite authors to present original research articles as well as review articles focusing on epigenetic regulation and its potential clinical application in women's diseases. Prospective topics include, but are not limited to:

  • DNA methylation and gene silencing mechanisms in gynecologic cancer
  • Gynecologic cancer-related genetic factors and their mutation, expression alteration, and aberrant modification in cancer progression
  • Application of epigenetic biomarkers for gynecologic cancer screening, monitoring, diagnosis, and prognosis
  • Development and application of epigenetic modification drugs for the prevention and treatment of gynecologic cancer patients
  • Epigenetic and imprinting regulation of placental function, fetus development, maintenance of pregnancy, and their involvement in preeclampsia and interuterine growth retardation
  • Epigenetic involvement in fertility and infertility, implication for IVF, and assisted reproduction

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ogi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 567260
  • - Editorial

Epigenetic Regulation in Reproductive Medicine and Gynecologic Cancers

Shi-Wen Jiang | Brian Brost | ... | Fan Jin
  • Special Issue
  • - Volume 2010
  • - Article ID 682504
  • - Research Article

Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis

Oscar Gee-Wan Wong | Zhen Huo | ... | Annie Nga-Yin Cheung
  • Special Issue
  • - Volume 2010
  • - Article ID 198709
  • - Review Article

Epigenetic Regulatory Mechanisms Associated with Infertility

Sheroy Minocherhomji | Prochi F. Madon | Firuza R. Parikh
  • Special Issue
  • - Volume 2010
  • - Article ID 870865
  • - Review Article

Specificity of Methylation Assays in Cancer Research: A Guideline for Designing Primers and Probes

Zeinab Barekati | Ramin Radpour | ... | Xiao Yan Zhong
  • Special Issue
  • - Volume 2010
  • - Article ID 437528
  • - Clinical Study

Effects of Assisted Reproduction Technology on Placental Imprinted Gene Expression

Yukiko Katagiri | Chizu Aoki | ... | Mineto Morita
  • Special Issue
  • - Volume 2010
  • - Article ID 965905
  • - Research Article

Study on the Imprinting Status of Insulin-Like Growth Factor II (IGF-II) Gene in Villus during 6–10 Gestational Weeks

Jianhong Chen | Qun Fang | ... | Yanmin Luo
  • Special Issue
  • - Volume 2010
  • - Article ID 120130
  • - Review Article

Preimplantation Genetic Screening: An Effective Testing for Infertile and Repeated Miscarriage Patients?

Ning Wang | Ying-Ming Zheng | ... | Fan Jin
  • Special Issue
  • - Volume 2010
  • - Article ID 302051
  • - Review Article

Oxidative Stress and DNA Methylation in Prostate Cancer

Krishna Vanaja Donkena | Charles Y. F. Young | Donald J. Tindall
  • Special Issue
  • - Volume 2010
  • - Article ID 498574
  • - Clinical Study

Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant Placenta

Yan-Min Luo | Qun Fang | ... | Guang-Lun Zhuang
  • Special Issue
  • - Volume 2010
  • - Article ID 989278
  • - Research Article

Effects of In Vitro Maturation on Histone Acetylation in Metaphase II Oocytes and Early Cleavage Embryos

Ning Wang | Fang Le | ... | Fan Jin
Obstetrics and Gynecology International
 Journal metrics
Acceptance rate12%
Submission to final decision68 days
Acceptance to publication28 days
CiteScore0.670
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