Research Article
Challenges in Managing Patients with Hereditary Cancer at Gynecological Services
Table 2
“Malignant” or “suspicious for malignancy” on peritoneal washing cytology without macroscopic abnormality.
| | Period of RRSO | SEE-FIM protocol | PWC in RRSO | Malignancy in PWC (macroscopic cancer) | Histopathologic examination | Further examination and follow-up therapy |
| Colgan [10] | NA | No | 35 | Malignant | Early stromal invasion of the ovarian cortex | Chemotherapy, 2nd look | Malignant | STIC | Observation | Malignant | NED | Extensive additional sectioning, reviewed by additional 2 cytopathologists, negative cytology at 2nd look, chemotherapy and 2nd look surgery |
| Manchanda [11] | 2005–2009 | No | 308 | Malignant | STIC | Hysterectomy, OMT + LND | Malignant | STIC | Hysterectomy, OMT + LND | Suspicious for malignancy | STIC | Hysterectomy, OMT + LND |
| Landon [12] | 2000–2012 | Mostly | 117 | Malignant | NED | Reviewed by additional 4 cytopathologists, multiple levels of tissue blocks examined, chemotherapy, 2nd look surgery | Suspicious for malignancy | Ovarian endometriosis and endosalpingiosis | Observation |
| Powell [13] | 1995–2009 | NA | 405 | Malignant | NED | Hysterectomy, OMT | Malignant | NED | Hysterectomy, OMT followed by 6 cycles of chemotherapy | Malignant | NED | Hysterectomy, OMT + LND followed by 6 cycles of chemotherapy |
| Blok [14] | 2000–2014 | Since 2006 | 267 | None | | |
| Total | | | 1132 | 11 (1.0%) | | |
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SEE-FIM: sectioning and extensively examining the fimbriated; PWC: peritoneal washing cytology; and STIC: serous tubal intraepithelial carcinoma.
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