Research Article
Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis
Table 4
Correlation of SOX2 methylation status with clinicopathological features in endometrial cancers.
| Clinicopathological Features | Presence of methylated alleles | Absence of methylated alleles | P-value | | Cases (%) | Cases (%) | |
| Histological type | | | | Endometrioid | 16 (66.7) | 32 (84.2) | .108 | Serous/CCC | 8 (33.3) | 6 (15.8) |
| Grade | | | | Low (1) | 7 (29.2) | 15 (39.5) | .409 | High (2-3) | 17 (70.8) | 22 (60.5) |
| Stage | | | | I | 19 (79.2) | 32 (84.2) | .613 | II–IV | 5 (20.8) | 6 (15.8) |
| Myometrial invasion | | | | 1/2 | 8 (72.7) | 27 (81.8) | .517 | 1/2 | 3 (27.3) | 6 (18.2) |
| Vascular invasion | | | | Negative | 12 (80.0) | 27 (73.0) | .596 | Positive | 3 (20.0) | 10 (27.0) |
| Involving cervix | | | | Negative | 13 (86.7) | 34 (91.9) | .962 | Positive | 2 (13.3) | 3 (8.1) |
| Age | | | | 45 | 9 (36.0) | 10 (26.3) | .413 | 45 | 16 (64.0) | 28 (73.7) |
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