TY - JOUR A2 - Bisht, Kirpal AU - Ahsan, Mohamed Jawed AU - Shastri, Sunil AU - Yadav, Rita AU - Hassan, Mohd. Zaheen AU - Bakht, Mohammed Afroz AU - Jadav, Surender Singh AU - Yasmin, Sabina PY - 2016 DA - 2016/11/24 TI - Synthesis and Antiproliferative Activity of Some Quinoline and Oxadiazole Derivatives SP - 9589517 VL - 2016 AB - In continuance of our search for newer antiproliferative agents we report herein the synthesis and antiproliferative studies of two series (5a–j and 10a–c) of heterocyclic compounds. All the new compounds were characterized by IR, NMR, and mass spectral data. The antiproliferative activity of 10 compounds (5a–j) was carried out on HeLa (cervix cancer cell line) and MDA-MB-435 (melanoma) and LC50, TGI, and GI50 were calculated, while the antiproliferative activity of 3 compounds (10a–c) was carried out against nine different panels of nearly 60 cell lines (NCI-60) according to the National Cancer Institute (NCI US) Protocol at 10 μM. 1-(7-Hydroxy-4-methyl-2-oxoquinolin-1(2H)-yl)-3-(4-methoxylphenyl)urea (5j) was found to have antiproliferative activity with GI50 of 35.1 μM against HeLa (cervix cancer cell line) and 60.4 μM against MDA-MB-435 (melanoma), respectively. The compounds 10a, 10b, and 10c showed antiproliferative activity with comparatively higher selectivity towards HOP-92 (Non-Small Cell Lung Cancer) with percent growth inhibitions (GIs) of 34.14, 35.29, and 31.59, respectively. SN - 2090-200X UR - https://doi.org/10.1155/2016/9589517 DO - 10.1155/2016/9589517 JF - Organic Chemistry International PB - Hindawi Publishing Corporation KW - ER -